Mechanisms of EGFR Resistance in Glioblastoma
نویسندگان
چکیده
منابع مشابه
Mechanisms of Cell Resistance in Glioblastoma Multiforme
Glioblastoma multiforme is the most common brain tumor in adults. It is characterized by a rapid clinical course and extremely unfavorable prognosis. The etiology and the molecular pathogenetic mechanisms are not entirely clear yet. Active proliferation, resistance to apoptosis and high angiogenicity are basic factors limiting the effect of standard therapy. A significant problem is the resista...
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Glioblastoma multiforme (GBM; WHO astrocytoma grade IV) is considered incurable owing to its inherently profound resistance towards current standards of therapy. Considerable effort is being devoted to identifying the molecular basis of temozolomide resistance in GBMs and exploring novel therapeutic regimens that may improve overall survival. Several independent DNA repair mechanisms that norma...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21228471